Our guided-mode resonance (GMR) technology is a novel label-free optical approach that can measure a wide variety of molecular interactions at the bench in real-time using a 96-well plate format. GMR signal(s) response is directly related to the binding density of the medium on the sensor surface. Applications include protein binding kinetic measurements, antibody binding and much more.
The heart of our guided-mode resonance (GMR) system is an optical element that filters light using a zeroth-order waveguide grating device which has a grating period smaller than the wavelength of incident light. This optical filter is highly sensitive to any changes occurring at the device surface. As a bioreaction occurs, tiny density changes can be detected by measuring spectral shifts in the resonantly reflected and/or transmitted light. Our proprietary nanostructured sensor element is embedded in the bottom of disposable microwell plates and reactions are monitored in real-time on the ResoSens Ultra-Mab Pro reader unit.
Real time measurements enable faster data acquisition with more information and binding characteristics on every test. Ability to measure multiple points in each well to maximize the number of tests per plate (up to 96 samples in parallel).
Can be used in numerous antibody characterization applications, including affinity analysis, epitope binning, selectivity and specificity screening. Due to its benchtop configuration – this flexible system can also be integrated with existing immunoassay robots, dispensing and plate stackers for full automation.
Our sensor plates come in standard 96-well microarray formats with our novel sensor element embedded in the bottom of the plate. The reaction occurs at the sensor surface and is compatible with conventional attachment chemistries such as biotinylated reagents. We continuously scan the reflected beam from the bottom of the plate, without having to penetrate through the sample. This enables small sample volumes (less than 45 microliters per well) and the ability to test crude samples during an assay.
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